![]() This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas “Mesoscopic Neurocircuitry” (No. Received: JanuAccepted: MaPublished: April 19, 2013Ĭopyright: © 2013 Fushiki et al. McCabe, Columbia University, United States of America Consistent with a role of chordotonal neurons in sensory feedback, these neurons were activated during larval peristalsis and acute inhibition of their activity decreased the speed of larval locomotion.Ĭitation: Fushiki A, Kohsaka H, Nose A (2013) Role of Sensory Experience in Functional Development of Drosophila Motor Circuits. These results suggest that neural activity mediated by specific sensory neurons is involved in the maturation of sensorimotor circuits in Drosophila and that there is a critical period for this plastic change. To narrow down the sensitive period, we applied shorter inhibition at various embryonic and larval stages and found that two-hour inhibition during 16–20 h AEL, but not at earlier or later stages, was sufficient to cause the effect. We found that inhibition of chordotonal organs, but not multidendritic neurons, led to a lasting decrease in the speed of larval locomotion. We applied Shibire-mediated inhibition for six hours during embryonic development (15–21 h after egg laying ) and studied its effects on peristalsis in the mature second- and third-instar larvae. We tested whether inhibiting the transmission of specific sensory neurons during this period would have lasting effects on the properties of the sensorimotor circuits. The peristalsis is initially slow and uncoordinated, but gradually develops into a mature pattern during late embryonic stages. ![]() Here we examined the effects of eliminating sensory inputs on the development of peristaltic movements in Drosophila embryos and larvae. While the existence of experience-dependent plasticity has been demonstrated for the visual and other sensory systems, it remains unknown whether this is also the case for motor systems. Neuronal circuits are formed according to a genetically predetermined program and then reconstructed in an experience-dependent manner. ![]()
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